This study dxaminedahe late pathological finding, clinical manifestation, and mortality in thirty-two rats with cerebral infarction induced by common carotid artery ligation.
Thirty-two rats were divided into three groups :Group A-al unilateral common carotid artery ligation group of twelve animals, Group B-a total common carotid artery ligation one side and partial common carotid artery ligation another side of eighteen animals,´ and Group C-bilateral common carotid arteries ligation of two animals.
All animals surviving for 3 weeks were sacrified by intracardial injection of 2M KCI 5cc and 2.5cc of 2% T.T.C. solution was infused into each common carotid arteries. The brain was rapidly removed and sectioned coronally and examined with the aid of a stereoscopic microscope for degree of T.T.C. stain and infarction. Brain was fixed and examined histologically.
The results were as follows
1) Mortality rate of each groups : a unilateral common carotid artery ligation group was 16,67%, a total.
Common carotid artery ligation one side and partial common carotid artery ligation another side group was 77.78%, and bilateral common arteries ligation group was 100%.
2) Clinical manifestation was showed as follows : hemiparesis, circling movement, abnormal seizure like activity, and ptosis.
3) Percent hemispheric volume infarction(% HVI) was 40% (mean value) in unilateral total common carotid artery ligation and 60% in total ligation one side and 46.25% in partial ligation another side.
4) The pathological change was signigicantly visible in bilateral ligation group.
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